Accelerate drug discovery

with high-throughput

kinetic screening

Confidently identify lead compounds and assess toxicity—faster

Unlock high-throughput kinetic screening with the FLIPR® Penta System—designed to accelerate drug discovery by enabling real-time monitoring of GPCR activity, ion channel function, and intracellular signaling. Confidently detect calcium and cAMP changes with fluorescence and luminescence assays, measure membrane potential shifts, and assess cardiotoxicity early using physiologically relevant 3D cardiomyocyte models.

With rapid “inject-and-read” kinetic enzyme workflows, the FLIPR Penta System streamlines biochemical screening and increases assay throughput.
Leverage our optimized FLIPR® Assay Kits—including Calcium, Membrane Potential, and Potassium—to generate biologically relevant data that drives smarter decisions and faster breakthroughs.

FLIPR Penta - an industry-renowned instrument for monitoring GPCRs and ion channels

 
Powered by a new, optional high-speed EMCCD camera and the new Peak Pro 2 software module, the new FLIPR Penta High-Throughput Cellular Screening System allows you to measure and analyze peaks of human-derived induced pluripotent stem cells (hiPSCs), differentiated into cardiomyocytes and neurons, up to 100 times per second and quickly cherry pick events such as Early Afterdepolarization-like events (EAD-like events), fibrillation, and irregular beating.
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Why Choose the FLIPR Penta System?

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Assess toxicity effects

The HS-EMCCD camera option allows for up to 100 measurements per second, providing detailed information about cardiomyocyte and/or neuronal oscillation. Combined with the ScreenWorks® Peak Pro 2 software analysis module, compound-induced pro-arrhythmic effects such as EAD-like events can be easily identified and flagged.

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Identify lead compounds

With seven LED sets, many filter options, and fluorescence or luminescence detection, the FLIPR system supports many assays, including calcium flux, potassium, and membrane potential.

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Configure to your throughput

The FLIPR Penta system can be configured to match user needs. From manual assays to automated solutions, to measuring 96-, 384-, or 1536-well samples at a time, to using wash or no-wash assay kits in adherent mode, the system can be upgraded as needs change in the future.

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Streamline Your Purchase

Get a tailored business plan to support your investment.

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Global Support

Access expert assistance wherever you are.

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Industry-Leading Expertise

Work with a highly qualified team dedicated to your success.

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Experience It First

Request a free demo to see the FLIPR Penta System in action.

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Easy Setup

Talk to our sales team today to arrange your demo!

 

Get Pricing

Applications of FLIPR Penta High-Throughput Cellular Screening System

  • GPCRs (G protein-coupled receptors) - Calcium and cAMP using fluorescence and luminescence cell-based assays
  • Membrane Potential
  • Cardiomyocyte screening
  • Potassium channels
  • Ligand-gated Calcium Channels
  • 3D assays
  • Biochemical assay
  • Toxicity testing

Key Features

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Complex event analysis

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Configurable optics

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User-changeable pipette modules

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Validated solution

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Ease of use

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Custom automation options

ScreenWorks Software with customizable protocols and data analysis for high-throughput kinetic assays

The FLIPR Penta system utilizes our ScreenWorks Software to define and run experimental protocols. Using a drag-and-drop interface, protocols can be easily set up to include:

  • Standard fluorescent or luminescent read modes or optional aequorin luminescence detection
  • Complex quadrant, multiple aspirations or multiple dispensing liquid handling
  • Single or ratiometric kinetic cell-based reading
  • Tip washing with up to two solvents
  • Simple-to-create automation protocols
  • Optional Peak Pro software module with easy signal oscillation anomaly detection

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Streamline Your Purchase

Get a tailored business plan to support your investment.

Handshake-Gn

Global Support

Access expert assistance wherever you are.

Webinar-Gn

Industry-Leading Expertise

Work with a highly qualified team dedicated to your success.

Ease-of-use-Gn-1

Experience It First

Request a free demo to see the FLIPR Penta System in action.

Asset 1

Easy Setup

Talk to our sales team today to arrange your demo!

Get Pricing

Customer Breakthrough

Dementia Research Institute at Cardiff University uses the FLIPR Penta System to study the role of microglia in Alzheimers disease

Dementia Research Institute at Cardiff University uses the FLIPR Penta System to study the role of microglia in Alzheimer’s disease

The team utilized the FLIPR Penta to compare the response of microglia from patients with high Alzheimer's risk to those from patients with low Alzheimer's risk when exposed to known calcium modulators. These comparisons aimed to identify discrepancies in calcium signaling between diseased and non-diseased cells, potentially shedding light on the underlying pathology.

“The FLIPR Penta surpasses the efficiency of an inverted microscope by enabling me to image a significantly larger quantity of cells and samples. Remarkably, it allows me to capture approximately 100 times more samples daily.”      - Dr. Emily Maguire

We Empower Scientists to Advance Discovery

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