FLIPR Penta High-Throughput Cellular Screening System

Unlock high-throughput kinetic screening with the FLIPR Penta System, designed to accelerate drug discovery by enabling real-time monitoring of GPCR activity, ion channel function, and intracellular signaling. Detect calcium and cAMP changes with fluorescence and luminescence assays, measure membrane potential shifts, and assess cardiotoxicity early using 3D cardiomyocyte models. With fast “inject and read” kinetic enzyme assays, the FLIPR Penta System streamlines biochemical workflows, increasing assay throughput. Leverage powerful assay kits—including FLIPR Calcium, Membrane Potential, and Potassium Assay Kits—to generate biologically relevant data for pharmaceutical breakthroughs.

An industry-renowned instrument for monitoring GPCRs and ion channels

Powered by a new, optional high-speed EMCCD camera and the new Peak Pro 2 software module, the new FLIPR® Penta High-Throughput Cellular Screening System allows you to measure and analyze peaks of human-derived induced pluripotent stem cells (hiPSCs), differentiated into cardiomyocytes and neurons, up to 100 times per second and quickly cherry pick events such as Early Afterdepolarization-like events (EAD-like events), fibrillation, and irregular beating.

The FLIPR Penta system utilizes our ScreenWorks Software to define and run experimental protocols. Using a drag-and-drop interface, protocols can be easily set up to include:

Standard fluorescent or luminescent read modes or optional aequorin luminescence detection
Complex quadrant, multiple aspirations or multiple dispensing liquid handling
Single or ratiometric kinetic cell-based reading
Tip washing with up to two solvents
Simple-to-create automation protocols
Optional Peak Pro software module with easy signal oscillation anomaly detection