Deeper insights for every lab

 

HCS.ai NEW-2

Switch to our next-generation imaging platform — whether you're upgrading or replacing, get up to 20% discount*

Every dataset holds more than images—it holds answers. The new ImageXpress HCS.ai High-Content Screening System goes beyond data capture, delivering high-speed acquisition, AI-powered analysis, and advanced imaging to turn complex data into discoveries.

Built for 2D and 3D assays, it offers high-definition imaging, deep-learning segmentation, and a modular, upgradeable design that evolves with your research. More than an imaging system, ImageXpress HCS.ai accelerates workflows, enhances reproducibility, and unlocks deeper insights to drive scientific progress.

Capabilities

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Adaptable for future research needs

Your research evolves—so should your imaging system. The modular, upgradable design allows you to customize your setup today and expand capabilities as your needs grow, eliminating the need for costly replacements.

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Twice the speed**

Speed matters. Image a 96-well plate in under 90 seconds or complete 3D volumetric analysis of a 384-well plate in just 25 minutes with a redesigned optical system. Seamlessly integrate into automated workflows for even greater efficiency.

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Superior data quality

Get deeper insights with 2x better signal-to-background** using a 95% peak quantum efficiency sCMOS camera, deep-tissue imaging, and AI-driven IN Carta Image Analysis Software. Detect subtle phenotypic changes, improve segmentation, and unlock complex biological insights faster.

Take a quick tour of the ImageXpress HCS.ai.

Let our application scientist take you through the features of the new ImageXpress® HCS.ai system, give you a glimpse of MetaXpress® Acquire, and demonstrate the capabilities of IN Carta® Image Analysis Software. 

Save up to 20% off*

Now’s the perfect time for the new ImageXpress HCS.ai High-Content Screening System with up to 20% off the list price.
 
  • Fast-track your research with twice the acquisition speed and 2x better signal-to-background**
  • Start screening in minutes with the intuitive MetaXpress Acquire software
  • Unlock deeper insights with AI-powered IN Carta Image Analysis
  • Flexible purchasing options including trade-in programs and leasing
Valid until: October 28, 2025

Get Pricing

A system that evolves with you

The ImageXpress HCS.ai system features a modular design and a wide array of configuration options, allowing for customization to meet your current needs and on-site upgrades as your requirements evolve - eliminating the need to purchase a new system.
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AI-powered cell imaging is here — no coding, just discovery

IN Carta Image Analysis Software

Provides robust, quantitative results from complex biological images and datasets

  • Achieve flawless cell segmentation

  • Train custom AI models in a single click

  • Classify subtle phenotypic changes with hundreds of features

  • Analyze the most challenging 2D, 3D, and 4D datasets
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MetaXpress Acquire High-Content Image Acquisition Software

Intuitive image acquisition software for a wide range of applications

 

MetaXpress Acquire High-Content Image Acquisition Software is a comprehensive solution for high-content imaging, designed for use with our ImageXpress HCS.ai High-Content Screening System. An intuitive interface and guided workflows streamline even complex imaging assays, enabling you to start generating data in minutes. Seamless integration with our AI-powered IN Carta Image Analysis software empowers you to unlock new discoveries through the power of machine learning.

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From image to insight—faster than ever

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The ImageXpress HCS.ai enables you to perform a vast range of assays on more physiologically relevant cell models to unlock deeper insights and maximize research outcomes. Obtain high-quality images, including from long-term, live-cell experiments, 3D cell models and multiplexed phenotypic screens, and then leverage AI-powered IN Carta Image Analysis Software to answer challenging biological questions. 

See a few beautiful examples below!

  

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10X Zebrafish C03 (1) (1)
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Spheroid mask in 3D viewer in IN Carta

Easily configure the ImageXpress HCS.ai system to meet your needs

Configure imagexpress HCS.ai Image

Save up to 20% off*

Now’s the perfect time for the new ImageXpress HCS.ai High-Content Screening System with up to 20% off the list price.
 
  • Fast-track your research with twice the acquisition speed and 2x better signal-to-background**
  • Start screening in minutes with the intuitive MetaXpress Acquire software
  • Unlock deeper insights with AI-powered IN Carta Image Analysis
  • Flexible purchasing options including trade-in programs and leasing
Valid until: October 28, 2025

Get Pricing

Molecular Devices: A life science company

We journey alongside researchers, combining next-gen technology and deep expertise to spark bold breakthroughs that push research boundaries and transform lives worldwide.
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We’re a trusted life-science partner to researchers around the world

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*Purchase order must reference promotion code EU-HCS.ai-Promo20-H225. The offer is to purchase the ImageXpress® HCS.ai High-Content Screening System for up to 20% off the list price. Valid until December 12, 2025. The offer does not include shipping and handling, installation or training. The offer does not include any other options or accessories. This promotion cannot be combined with any other promotions or discounts. No substitutions or swap outs. The discount is not convertible to cash. Promotion is not valid for standing orders. All prices exclude delivery charges and local taxes, which are the responsibility of the customer. Purchase orders must be received by December 12, 2025 and delivery completed by December 31, 2025. This offer is valid only to customers in Europe when buying directly from Molecular Devices. Commercial organizations are excluded from this offer. Delivery terms are FCA (Free Carrier) and seller’s shipping facility (Incoterms 2010). Offer void where prohibited. All Molecular Devices products are for research use only. Other restrictions may apply. For our full standard terms and conditions of sale, please visit https://www.moleculardevices.com/terms-and-conditions.

**Compared to the previous generation ImageXpress platform. The data is available on request.