Eliminate cardiotoxic compounds earlier in the drug discovery process
Traditional cardiotoxicity testing methods can take weeks or even months to complete, slowing down your research and drug development timelines. If you no longer want to rely on traditional, time-consuming, and costly methods for cardiotoxicity testing, we are here to help. Our state-of-the-art technology within the FLIPR Penta allows for rapid and accurate cardiotoxicity assessment, enabling you to identify potential issues earlier and make informed decisions faster.
The FLIPR High-Throughput Cellular Screening System is an industry-renowned instrument for monitoring GPCRs and ion channels that allows you to measure and analyze patterns of calcium oscillations (changes in intracellular Ca2+ flux) of cardiomyocytes. Images can be taken up to 100 times per second, and patterns can be quickly analyzed using more than 30 various measurements.
Obtain robust multi-parameter cytotoxicity data
Quickly cherry-pick events such as Early Afterdepolarization-like events (EAD-like events), fibrillation, and irregular beating
Measure 384 samples in minutes rather than hours
FLIPR Penta allows us to administer precise quantities of reagents to each well simultaneously and records changes both before and after the addition of the compound
Screen up to 32,000 compounds per day
Simultaneous compound dispensing and adjustable throughput allows to screen up to 100 plates and up to 32,000 compounds per day (using 384 well plate)
Get started with the FLIPR Penta today
Don't let traditional cardiotoxicity testing methods hold you back. Let's work together to revolutionize the way we approach cardiotoxicity testing. Reach out to us today to discuss how our specialists can help you with your requirements.
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Are you interested in a 3D biology workflow solution for cardiotoxicity evaluation?
In this video, Simon Lydford, Senior Application Scientist at Molecular Devices, presents his poster "Structural organization and functional analysis of compound responses in 3D human iPSC-derived cardiac tri-culture microtissues" on the aforementioned workflow, explains why 3D cell models are becoming more common and how the FLIPR Penta system can perform functional assays on such models, such as cardiac microtissues.
This workflow can be used during drug discovery and development to screen compounds for potential cardiotoxic effects. Whilst the FLIPR Penta allows for exceptionally fast, high-throughput measurements of calcium oscillation patterns, the ImageXpress High Content Imaging System allows for the fast acquisition and analysis of complex biological samples.
