--- title: Pave the way to neuroscience breakthroughs with Axon Patch-Clamp Intruments™ description: Turn your idea into a breakthrough with the Axon Instruments™. Amplifiers, digitizer, and most widely-used patch-clamp electrophysiology software - pCLAMP. --- [![Molecular Devices, LLC](https://info.moleculardevices.com/hs-fs/hubfs/raw_assets/public/Moldev/MD-Theme/images/mol-dev-logo-hs.png?width=220&height=50&name=mol-dev-logo-hs.png)](https://www.moleculardevices.com/) ## SCALE UP ELECTROPHYSIOLOGY # PAVE THE WAY TO NEUROSCIENCE BREAKTHROUGHS [Inquire about the solution](https://info.moleculardevices.com/applications/dd/cns/neurosciencewithaxon#requestquote) ![DD 1550B 700B 200B Angle\_NB-1](https://info.moleculardevices.com/hs-fs/hubfs/DD%201550B%20%20700B%20200B%20Angle_NB-1.png?width=1200&height=862&name=DD%201550B%20%20700B%20200B%20Angle_NB-1.png "DD 1550B 700B 200B Angle_NB-1") ## Accelerate your neuroscientific discoveries with Axon Patch-Clamp Instruments Our comprehensive solutions for patch-clamping facilitate the entire range of patch-clamp technique experiments from the smallest single-channel to the largest macroscopic recordings. The addition of Axon pCLAMP™ 11 Software Suite creates a streamlined workflow, allowing for sophisticated and efficient experiments, and higher quality data generation so you can make a scientific breakthrough even faster. ![Axon workflow\_20230214](https://info.moleculardevices.com/hs-fs/hubfs/Axon%20workflow_20230214.jpg?width=2968&height=1100&name=Axon%20workflow_20230214.jpg "Axon workflow_20230214") ![Record-Gn](https://info.moleculardevices.com/hs-fs/hubfs/Record-Gn.png?width=61&height=61&name=Record-Gn.png) #### Maximize signal-to-noise ratio The Axopatch™ 200B Amplifier offers one of the lowest-noise, single-channel recordings available via an innovative actively cooled headstage with capacitor-feedback technology. ![Noise-cancelling-Gn](https://info.moleculardevices.com/hs-fs/hubfs/Common/Noise-cancelling-Gn.png?width=435&height=434&name=Noise-cancelling-Gn.png) #### Eliminate line-frequency noise The HumSilencer™ feature removes 50/60 hz line-frequency noise within one second with a single mouse click. ![Workflow-Gn](https://info.moleculardevices.com/hs-fs/hubfs/Common/Workflow-Gn.png?width=435&height=435&name=Workflow-Gn.png) #### Streamline workflows pCLAMP Software offers a selection of modules and tools that simplifies setup and enables automation of parameters. ## Patch-clamp software trusted by researchers worldwide: 41,600+ citations for pCLAMP ## Get started with Axon today Get in touch with our specialists now to find out how we can help you with your research. Remember to sign up for our mailing list to stay up to date with the latest electrophysiology news, applications, and updates.  ![pClamp-monitor](https://info.moleculardevices.com/hs-fs/hubfs/CNS/pClamp-monitor.png?width=400&height=321&name=pClamp-monitor.png "pClamp-monitor")   ### Inquire about the instruments ![](https://play.vidyard.com/X5bEMAt5nE5rtfa5g7t4hq.jpg) ### University of São Paulo uses Axon for patch-clamp recordings in brain slices Meet Professor Ricardo Leão, who presents his poster on how neurons in the rodent's nucleus of the solitary tract respond to changes in cytoplasmic ATP levels, shedding light on their remarkable membrane potential alterations. ### pCLAMP 11 acquisition and analysis software #### Fast and effective data analysis turns data into actionable insights and publication-ready results. - With Clampex 11, longer and more sophisticated protocols can be programmed. - With ClampFit 11, more precise measurement and faster data analysis are now possible. [Inquire about the solution](https://info.moleculardevices.com/applications/dd/cns/neurosciencewithaxon#requestquote) ## These researchers used Axon patch-clamp systems to achieve neuroscientific breakthroughs ![nichelle-jackson-detail-1](https://info.moleculardevices.com/hs-fs/hubfs/nichelle-jackson-detail-1.jpg?width=843&height=497&name=nichelle-jackson-detail-1.jpg) University of Michigan uses Axon patch-clamp systems to investigate **NMDAR receptor blockers**. ![allegheny-college-lab-photo-1](https://info.moleculardevices.com/hs-fs/hubfs/allegheny-college-lab-photo-1.png?width=900&height=531&name=allegheny-college-lab-photo-1.png) Allegheny College uses Axon patch-clamp systems to investigate how amyloid beta peptide block ion channels in **Alzheimer’s disease**. ![customer-hero-univeristy-of-texas-balaji-axon-patch-3](https://info.moleculardevices.com/hs-fs/hubfs/customer-hero-univeristy-of-texas-balaji-axon-patch-3.png?width=900&height=530&name=customer-hero-univeristy-of-texas-balaji-axon-patch-3.png) University of Texas uses Axon patch-clamp systems to evaluate signaling mechanisms in the brain underlying **memory and recall**. ## Applications Our solutions can be used across almost the entire range of electrophysiology techniques, from single channel to whole cell to extracellular field-potential recording. ### Extracellular recording   • Single-unit recording • Multi-unit recording • Field-potential recordings • Amperometry/voltammetry ![iStock\_000010100054Medium (2)](https://info.moleculardevices.com/hs-fs/hubfs/iStock_000010100054Medium%20(2).jpg?width=400&height=250&name=iStock_000010100054Medium%20(2).jpg "iStock_000010100054Medium (2)") ### Intracellular recording   • Cell-attached/excised patch-clamp • Whole-cell voltage-clamp • Whole-cell current-clamp • Sharp-electrode ![AdobeStock\_42939862](https://info.moleculardevices.com/hs-fs/hubfs/AdobeStock_42939862.jpeg?width=357&height=250&name=AdobeStock_42939862.jpeg "AdobeStock_42939862") - - - - ©2026 Molecular Devices, LLC. All rights reserved. - [Terms & Conditions](https://www.moleculardevices.com/terms-and-conditions) - [Privacy Policy](https://www.moleculardevices.com/privacy) - [Do Not Sell or Share My Data](https://www.moleculardevices.com/california-consumer-rights-notice) - [Online Terms of Use](https://www.moleculardevices.com/online-terms-use) - [Trademarks](https://www.moleculardevices.com/trademarks) - [Careers](https://jobs.danaher.com/global/en/molecular-devices) - [Support](https://www.moleculardevices.com/service-support) - [Contact Us](https://www.moleculardevices.com/contact) - [Sitemap](https://www.moleculardevices.com/sitemap) - [Danaher Life Sciences](https://lifesciences.danaher.com/) [![media\_15e6337050964bd17b8d50971b5bfc8604268b016](https://info.moleculardevices.com/hubfs/media_15e6337050964bd17b8d50971b5bfc8604268b016.png "media_15e6337050964bd17b8d50971b5bfc8604268b016")](https://www.danaher.com/)